• English
  • Português

Toxicology

Guedes, I.A.; Rachid, C.T.C.C.; Rangel, L.M., Silva, L.H.S.; Bisch, P.M.; Azevedo. S.M.F.O.; Pacheco. A.B.F. (2018) Close link between harmful cyanobacterial dominance and associated bacterioplankton in a tropical eutrophic reservoir. Front. Microbiol. 9:424

Oliveira, V.R.; Cavalcante, G.M.; Casquilho, N.V.; Moreira-Gomes. M.D.; Soares, M.S.; Azevedo, S.M.F.O.; Lima, L.M.; Barreiro, E.J.; Takiya, C.M.; Zin,W.A, (2018).Lung and liver responses to 1- and 7-day treatments with LASSBio-596 in mice subchronically intoxicated by microcystin-LR. Toxicon. 141:1-8.

Casquilho,N.V.; Moreira-Gomes,M;D.; Magalhães,C.B.; Okuro,R.T.; Ortenzi,V.H.; Feitosa-Lima,E.K.; Lima,L.M.; Barreiro,E.J.; Soares,R.M.; Azevedo,Sandra M.F.O.; Valença,S.S.; Fortunato,R.S.; Carvalho,A.R.; Zin,W. A. (2018), Oxidative imbalance in mice intoxicated by microcystin-LR can be minimized. v.144:75-82

Cabral,B.C.A.; Hoffmann,L.; Budowle,B.; Ürményi,T.P.; Moura-Neto,R.S.; Azevedo,S.M.F.O.; Silva,R.(2018). Planktonic microbial profiling in water samples from a Brazilian Amazonian reservoir. MicrobiologyOpen. 7(2):e00523

Hoffmann, L., Ramos, R., Guedes, I. A., Costa, P. F., Miguel, C., Azevedo, S., & Silva, R. (2017). Draft Genome Sequences of Two Brazilian Cyanobacterial Strains of Cylindrospermopsis raciborskii: Differences in Membrane Transporters, Saxitoxin Production, and Antioxidant Activities. Genome announcements, 5(43), e00879-17

Silva, R. C. , Liebel, S. ,Oliveira, H. H. P. , Ramsdorf, W. A. , Garcia, J. R. E. , Azevedo, S. M. F. O. , Magalhães, V. F. , Ribeiro, C. A.O. , Filipak Neto, F. (2017) . Cylindrospermopsin effects on cell viability and redox milieu of Neotropical fish Hoplias malabaricus hepatocytes. Fish Physiology and Biochemistry, 43(5):1237-1244.

Carvalho, G,M.C.; Oiveira, V.R.; Casquilho,N.V.; Araujo,A.C.P.; Soares, Raquel Moraes ;  Azevedo,S.M.F.O.; Pires, K.M.P.; Valença, S.S.; Zin, W.A.  (2016). Pulmonary and hepatic injury after sub-chronic exposure to sublethal doses of microcystin-LR. Toxicon, v. 112, p. 51-58.

Liebel, S.; Ribeiro, C.A.O.; Magalhães, V.F.; Silva R.C.; Rossi, S.C.; Randi. M.A.F.; Flipak-Neto, F. (2015). Low concentrations of cylindrospermopsin induce increases of reactive oxygen species levels, metabolism and proliferation in human hepatoma cells (HepG2). Toxicology in Vitro, v. 29, p. 479-488.

Oliveira, V.R.. Mancini, V.G.L.; Pinto,E.F.; Soares, R.M.; Azevedo. S.M.F.O.; Macchione,M.; Carvalho, A.; Zin.W.A.  (2015). Repeated intranasal exposure to microcystin-LR affects lungs but not nasal epithelium in mice. Toxicon, v. 104, p. 14-18.

Oliveira, V.R.; Avila, M.B.; Carvalho, G.M.C.;Azevedo, S.M.F.O.;Lima, L.M.; Barreiro, E.J.; Carvalho, A.R.; Zin, W.A. . (2015). Investigating the therapeutic effects of LASSBio-596 in an in vivo model of cylindrospermopsin-induced lung injury. Toxicon, v. 94, p. 29-35.

Silva, C.A.; Morais, E.C.P.; Costa, M.D.M.; Ribas, J.L.C.; Guiloski,I.C.; Rasmsdor, W.A.; Zanata, Si.M.; Cestari, M.J.,  Ribeiro, C.A.O.; Magalhães, V.F. ; Trudeau,V. Assis, H.C.S. (2014) . Saxitoxins induce cytotoxicity, genotoxicity and oxidative stress in teleost neurons in vitro. Toxicon, v. 86, p. 8-15.

Fonseca,  A. L. ; Silva, J. ; Nunes, E. A. ; Azevedo, S. M. F. O.;Soares, R. M. (2014). In vivo genotoxicity of treated water containing the cylindrospermopsin-producer  Cylindrospermopsis raciborskii. Journal of Water and Health, v. 12, p. 474-483.

Mattos, L.J. ; Valença, S.S. ; Azevedo, S.M.F.O. ; Soares, R.M. (2014). Dualistic evolution of liver damage in mice triggered by a single sublethal exposure to Microcystin-LR. Toxicon (Oxford), v. 83, p. 43-51.

Hilborn, E.D.; Soares, R.M.; Servantes, J.C.; Delgado, A.G., Magalhães, V.F.; Carmichael,W.W.; Azevedo, S.M.F.O. (2013) . Sublethal Microcystin Exposure and Biochemical Outcomes among Hemodialysis Patients. Plos One, v. 8, p. e69518.

Lowe,J., Souza-Menezes,J., Freire,D.S., Mattos,L.J., Castiglione,R.C., Barbosa,C.M.L., Santiago,L., Ferrão,F.M., Cardoso,L.H.D., Silva,R.T. da, Vieira-Beiral,H.J., Vieyra,A., Morales, M.M., Azevedo,S.M.F.O., Soares,R.M. (2012). Single sublethal dose of microcystin-LR is responsible for different alterations in biochemical, histological and physiological renal parameters. Toxicon 59(6):601-609.

Oliveira,V.R., Carvalho,G.M.C., Avila,M.B., Soares,R.M., Azevedo,S.M.F.O. , Ferreira,T.S., Valença,S.S, Faffe,D.S., Zin,W.A. (2012). Time-dependence of lung injury in mice acutely exposed to cylindrospermopsin. Toxicon, 60:764-772.

Casquilho,N.V.; Carvalho,G.M.C.; Alves,J.L.C.R.; Machado,M.N.; Soares,R.M.; Azevedo,S.M.F.O.; Lima,L.M.; Barreiro,E.J.; Valenca,S.S.; Carvalho,A.R.; Faffe,D.S.; Zin,W.A. (2011). LASSBio 596 per os avoids pulmonary and hepatic inflammation induced by microcystin-LR. Toxicon. 58:195-201.

Liebel, S., Ribeiro, C.A.O., Ramsdorf, W.A., Cestari, M.M., Magalhães, V.F., Garcia, J.R.E., Esquivel, B.M., Filipak Neto, F. (2011). Cellular responses of Prochilodus lineatus hepatocytes after cylindrospermopsin exposure. Toxicology in Vitro. 25(7):1493-1500

Carvalho, G. M. C., Oliveira, V. R., Soares, R. M., Azevedo, S. M. F. O., Lima, L. M., Barreiro, E. J. L. et al. (2010). Can LASSBio-596 and dexamethasone treat acute lung and liver inflammation induced by microcystin-LR? Toxicon, 56:604-612.

Dörr, F. A., Pinto, E., Soares, R. M., Azevedo, S. M. F. O. (2010). Microcystins in South American aquatic ecosystems: Occurrence, toxicity and toxicological assays. Toxicon, 56: 1247-1256.

Humpage, A. R., Magalhães, V.F., Froscio, S.M.(2010). Comparison of analytical tools and biological assays for detection of paralytic shellfish poisoning toxins. Anal Bioanal Chem. 397:1655–1671

Soares, R,M. (2009). Toxicologia de cianotoxinas: Microcistinas as estrelas do tema. Oecol. Brasilienses, 13(2):259-271

Hilborn, E. D., Carmichael, W. W., Soares, R. M., Yuan, M., Servaites, J. C., Barton, H. A. et al. (2007). Serologic evaluation of human microcystin exposure. Environ.Toxicol., 22: 459-463.

Soares, R. M., Cagido, V. R., Ferraro, R. B., Meyer-Fernandes, J. R., Rocco, P. R. M., Zin, W. A., Azevedo, S.M.F.O. (2007). Effects of microcystin-LR on mouse lungs. Toxicon, 50: 330-338.

Coelho-Souza, S. A., Guimarães, J. R. D., Mauro, J. B. N., Miranda, M. R., Azevedo, S. M. F. O. (2006). Mercury methylation and bacterial activity associated to tropical phytoplankton. Science of the Total Environment, 364: 188-199.

Gonçalvez, E. A. P., Dalboni, M. A., Peres, A. T., Manfredi, A. P., Manfredi, S. R., Azevedo, S. M. F. O. et al. (2006). Effects of microcystin on leukocyte viability and function. Toxicon, 47: 774-779.

Soares, R. M., Yuan, M., Servaites, J. C., Delgado, A., Magalhães, V. F., Hiborn, E. D. et al. (2006). Sublethal exposure from microcystins to renal insufficiency patients in Rio de Janeiro, Brazil. Environmental Toxicology, 21: 95-103.

Hilborn, E. D., Carmichael, W. W., Yuan, M., Azevedo, S. M. F. O. (2005). A simple colorimetric method to detect biological evidence of human exposure to microcystins. Toxicon, 46: 218-221.

Picanço, M. R., Soares, R. M., Cagido, V. R., Azevedo, S. M. F. O., Rocco, P. R. M., Zin, W. A. (2004). Toxicity of cyanobacterial extract containing microcystins to mouse lungs. Brazilian Journal of Medical and Biological Research, 37: 1225-1229.

Azevedo, S. M. F. O., Carmichael, W. W., Jochimsen, E., Rinehart, K., Lau, S., Shaw, G. et al. (2002). Human intoxication by microcystins during renal dialysis treatment in Caruaru - Brazil. Toxicology, 181, pp. 441-446.

Komarek, J., Azevedo, S.M.F.O., Domingos, P., Komarkova, J., Tichy, M. (2001). Background of the Caruaru tragedy: a case taxonomic study of toxic cyanobacteria. Archiv für Hydrobiologie. , 140:9-29.

Carmichael, W.W., Azevedo, S.M.F.O., An, J.S., Molica, R.J.R., Jochimsen, E.M., Lau, S., Rinehart, K.L., Shaw, G.R., Eaglesham, G.K. (2001). Human fatalities from Cyanobacteria: Chemical and Biological Evidence for cyanotoxins. Journal of Environmental Science and Health Part A - Environmental Science and Engineering & Toxic and Hazardous Substance Control. 109:663-668.

Azevedo, S. M. F. O. (1998). Toxinas de Cianobacterias: causas e consequências para a saúde pública. Medicina on line [On-line]. 1(3) link: http://www.medonline.com.br/med_ed/med3/microcis.htm

Jochimsen, E. M., Carmichael, W. W., An, J. S., Cardo, D., Cookson, S. T., Holmes, C. E. M. et al. (1998). Liver failure and death following exposure to microcystin toxins at a hemodialysis center in Brazil. The New England Journal of Medicine, 36: 373-378.