Moraes, A.C.N. ; Freire, D.S. ; Habibi, H. ; Lowe, J. ; Magalhães, V.F. .(2021).Cylindrospermopsin impairs tubular transport function in kidney cells LLC-PK1. Toxicology Letters, v. 344, p. 26-33.

Lima-Filho, C.M. ; Nogaroli, L. ; Hedin-Pereira, C.; Azevedo, S.M.F.O. ; Soares, R.M. . (2020). Effects of saxitoxins exposure on oligodendrocyte development in mouse neonates. Toxicon, v. 188, p. 89-94.

Moraes, A.C.N. ; Magalhães, V.F. . (2018). Renal tubular damage caused by cylindrospermopsin (cyanotoxin) in mice. Toxicology Letters, v. 286, p. 89-95.

Guedes, I.A.; Rachid, C.T.C.C.; Rangel, L.M., Silva, L.H.S.; Bisch, P.M.; Azevedo. S.M.F.O.; Pacheco. A.B.F. (2018) Close link between harmful cyanobacterial dominance and associated bacterioplankton in a tropical eutrophic reservoir. Front. Microbiol. 9:424

Oliveira, V.R.; Cavalcante, G.M.; Casquilho, N.V.; Moreira-Gomes. M.D.; Soares, M.S.; Azevedo, S.M.F.O.; Lima, L.M.; Barreiro, E.J.; Takiya, C.M.; Zin,W.A, (2018).Lung and liver responses to 1- and 7-day treatments with LASSBio-596 in mice subchronically intoxicated by microcystin-LR. Toxicon. 141:1-8.

Casquilho,N.V.; Moreira-Gomes,M;D.; Magalhães,C.B.; Okuro,R.T.; Ortenzi,V.H.; Feitosa-Lima,E.K.; Lima,L.M.; Barreiro,E.J.; Soares,R.M.; Azevedo,Sandra M.F.O.; Valença,S.S.; Fortunato,R.S.; Carvalho,A.R.; Zin,W. A. (2018), Oxidative imbalance in mice intoxicated by microcystin-LR can be minimized. v.144:75-82

Cabral,B.C.A.; Hoffmann,L.; Budowle,B.; Ürményi,T.P.; Moura-Neto,R.S.; Azevedo,S.M.F.O.; Silva,R.(2018). Planktonic microbial profiling in water samples from a Brazilian Amazonian reservoir. MicrobiologyOpen. 7(2):e00523

Oliveira, V.R.; Carvalho, G.M.C.; Casquilho, N.V.; Moreira-Gomes, M.D.; Soares, R.M.; Azevedo, S.M.F.O.; Lima, L.M.; Barreiro, E.J.; Takiya, C.M.; Zin, W.A. (2018). Lung and liver responses to 1- and 7-day treatments with LASSBio-596 in mice subchronically intoxicated by microcystin-LR. Toxicon, v. 141, p. 1-8.

Silva, R. C. , Liebel, S. ,Oliveira, H. H. P. , Ramsdorf, W. A. , Garcia, J. R. E. , Azevedo, S. M. F. O. , Magalhães, V. F. , Ribeiro, C. A.O. , Filipak Neto, F. (2017) . Cylindrospermopsin effects on cell viability and redox milieu of Neotropical fish Hoplias malabaricus hepatocytes. Fish Physiology and Biochemistry, 43(5):1237-1244.

Hoffmann, L., Ramos, R., Guedes, I. A., Costa, P. F., Miguel, C., Azevedo, S., & Silva, R. (2017). Draft Genome Sequences of Two Brazilian Cyanobacterial Strains of Cylindrospermopsis raciborskii: Differences in Membrane Transporters, Saxitoxin Production, and Antioxidant Activities. Genome announcements, 5(43), e00879-17

Carvalho, G,M.C.; Oiveira, V.R.; Casquilho,N.V.; Araujo,A.C.P.; Soares, Raquel Moraes ;  Azevedo,S.M.F.O.; Pires, K.M.P.; Valença, S.S.; Zin, W.A.  (2016). Pulmonary and hepatic injury after sub-chronic exposure to sublethal doses of microcystin-LR. Toxicon, v. 112, p. 51-58.

Liebel, S.; Ribeiro, C.A.O.; Magalhães, V.F.; Silva R.C.; Rossi, S.C.; Randi. M.A.F.; Flipak-Neto, F. (2015). Low concentrations of cylindrospermopsin induce increases of reactive oxygen species levels, metabolism and proliferation in human hepatoma cells (HepG2). Toxicology in Vitro, v. 29, p. 479-488.

Oliveira, V.R.. Mancini, V.G.L.; Pinto,E.F.; Soares, R.M.; Azevedo. S.M.F.O.; Macchione,M.; Carvalho, A.; Zin.W.A.  (2015). Repeated intranasal exposure to microcystin-LR affects lungs but not nasal epithelium in mice. Toxicon, v. 104, p. 14-18.

Oliveira, V.R.; Avila, M.B.; Carvalho, G.M.C.;Azevedo, S.M.F.O.;Lima, L.M.; Barreiro, E.J.; Carvalho, A.R.; Zin, W.A. . (2015). Investigating the therapeutic effects of LASSBio-596 in an in vivo model of cylindrospermopsin-induced lung injury. Toxicon, v. 94, p. 29-35.

Silva, C.A.; Morais, E.C.P.; Costa, M.D.M.; Ribas, J.L.C.; Guiloski,I.C.; Rasmsdor, W.A.; Zanata, Si.M.; Cestari, M.J.,  Ribeiro, C.A.O.; Magalhães, V.F. ; Trudeau,V. Assis, H.C.S. (2014) . Saxitoxins induce cytotoxicity, genotoxicity and oxidative stress in teleost neurons in vitro. Toxicon, v. 86, p. 8-15.

Fonseca,  A. L. ; Silva, J. ; Nunes, E. A. ; Azevedo, S. M. F. O.;Soares, R. M. (2014). In vivo genotoxicity of treated water containing the cylindrospermopsin-producer  Cylindrospermopsis raciborskii. Journal of Water and Health, v. 12, p. 474-483.

Mattos, L.J. ; Valença, S.S. ; Azevedo, S.M.F.O. ; Soares, R.M. (2014). Dualistic evolution of liver damage in mice triggered by a single sublethal exposure to Microcystin-LR. Toxicon (Oxford), v. 83, p. 43-51.

Hilborn, E.D.; Soares, R.M.; Servantes, J.C.; Delgado, A.G., Magalhães, V.F.; Carmichael,W.W.; Azevedo, S.M.F.O. (2013) . Sublethal Microcystin Exposure and Biochemical Outcomes among Hemodialysis Patients. Plos One, v. 8, p. e69518.

Lowe,J., Souza-Menezes,J., Freire,D.S., Mattos,L.J., Castiglione,R.C., Barbosa,C.M.L., Santiago,L., Ferrão,F.M., Cardoso,L.H.D., Silva,R.T. da, Vieira-Beiral,H.J., Vieyra,A., Morales, M.M., Azevedo,S.M.F.O., Soares,R.M. (2012). Single sublethal dose of microcystin-LR is responsible for different alterations in biochemical, histological and physiological renal parameters. Toxicon 59(6):601-609.

Oliveira,V.R., Carvalho,G.M.C., Avila,M.B., Soares,R.M., Azevedo,S.M.F.O. , Ferreira,T.S., Valença,S.S, Faffe,D.S., Zin,W.A. (2012). Time-dependence of lung injury in mice acutely exposed to cylindrospermopsin. Toxicon, 60:764-772.

Casquilho,N.V.; Carvalho,G.M.C.; Alves,J.L.C.R.; Machado,M.N.; Soares,R.M.; Azevedo,S.M.F.O.; Lima,L.M.; Barreiro,E.J.; Valenca,S.S.; Carvalho,A.R.; Faffe,D.S.; Zin,W.A. (2011). LASSBio 596 per os avoids pulmonary and hepatic inflammation induced by microcystin-LR. Toxicon. 58:195-201.

Liebel, S., Ribeiro, C.A.O., Ramsdorf, W.A., Cestari, M.M., Magalhães, V.F., Garcia, J.R.E., Esquivel, B.M., Filipak Neto, F. (2011). Cellular responses of Prochilodus lineatus hepatocytes after cylindrospermopsin exposure. Toxicology in Vitro. 25(7):1493-1500

Humpage, A. R., Magalhães, V.F., Froscio, S.M.(2010). Comparison of analytical tools and biological assays for detection of paralytic shellfish poisoning toxins. Anal Bioanal Chem. 397:1655–1671

Carvalho, G. M. C., Oliveira, V. R., Soares, R. M., Azevedo, S. M. F. O., Lima, L. M., Barreiro, E. J. L. et al. (2010). Can LASSBio-596 and dexamethasone treat acute lung and liver inflammation induced by microcystin-LR? Toxicon, 56:604-612.

Dörr, F. A., Pinto, E., Soares, R. M., Azevedo, S. M. F. O. (2010). Microcystins in South American aquatic ecosystems: Occurrence, toxicity and toxicological assays. Toxicon, 56: 1247-1256.

Soares, R,M. (2009). Toxicologia de cianotoxinas: Microcistinas as estrelas do tema. Oecol. Brasilienses, 13(2):259-271

Hilborn, E. D., Carmichael, W. W., Soares, R. M., Yuan, M., Servaites, J. C., Barton, H. A. et al. (2007). Serologic evaluation of human microcystin exposure. Environ.Toxicol., 22: 459-463.

Soares, R. M., Cagido, V. R., Ferraro, R. B., Meyer-Fernandes, J. R., Rocco, P. R. M., Zin, W. A., Azevedo, S.M.F.O. (2007). Effects of microcystin-LR on mouse lungs. Toxicon, 50: 330-338.

Coelho-Souza, S. A., Guimarães, J. R. D., Mauro, J. B. N., Miranda, M. R., Azevedo, S. M. F. O. (2006). Mercury methylation and bacterial activity associated to tropical phytoplankton. Science of the Total Environment, 364: 188-199.

Gonçalvez, E. A. P., Dalboni, M. A., Peres, A. T., Manfredi, A. P., Manfredi, S. R., Azevedo, S. M. F. O. et al. (2006). Effects of microcystin on leukocyte viability and function. Toxicon, 47: 774-779.

Soares, R. M., Yuan, M., Servaites, J. C., Delgado, A., Magalhães, V. F., Hiborn, E. D. et al. (2006). Sublethal exposure from microcystins to renal insufficiency patients in Rio de Janeiro, Brazil. Environmental Toxicology, 21: 95-103.

Hilborn, E. D., Carmichael, W. W., Yuan, M., Azevedo, S. M. F. O. (2005). A simple colorimetric method to detect biological evidence of human exposure to microcystins. Toxicon, 46: 218-221.

Picanço, M. R., Soares, R. M., Cagido, V. R., Azevedo, S. M. F. O., Rocco, P. R. M., Zin, W. A. (2004). Toxicity of cyanobacterial extract containing microcystins to mouse lungs. Brazilian Journal of Medical and Biological Research, 37: 1225-1229.

Azevedo, S. M. F. O., Carmichael, W. W., Jochimsen, E., Rinehart, K., Lau, S., Shaw, G. et al. (2002). Human intoxication by microcystins during renal dialysis treatment in Caruaru - Brazil. Toxicology, 181, pp. 441-446.

Komarek, J., Azevedo, S.M.F.O., Domingos, P., Komarkova, J., Tichy, M. (2001). Background of the Caruaru tragedy: a case taxonomic study of toxic cyanobacteria. Archiv für Hydrobiologie. , 140:9-29.

Carmichael, W.W., Azevedo, S.M.F.O., An, J.S., Molica, R.J.R., Jochimsen, E.M., Lau, S., Rinehart, K.L., Shaw, G.R., Eaglesham, G.K. (2001). Human fatalities from Cyanobacteria: Chemical and Biological Evidence for cyanotoxins. Journal of Environmental Science and Health Part A - Environmental Science and Engineering & Toxic and Hazardous Substance Control. 109:663-668.

Azevedo, S. M. F. O. (1998). Toxinas de Cianobacterias: causas e consequências para a saúde pública. Medicina on line [On-line]. 1(3) link:

Jochimsen, E. M., Carmichael, W. W., An, J. S., Cardo, D., Cookson, S. T., Holmes, C. E. M. et al. (1998). Liver failure and death following exposure to microcystin toxins at a hemodialysis center in Brazil. The New England Journal of Medicine, 36: 373-378.